Since this is a "Portable" executable, you do not launch it through Steam (doing so will likely make Steam verify the original files and overwrite your patch).
To avoid conflicts with Steam install, run a .reg script that nullifies Steam’s registry entries for this portable copy. (Available on Nexus as “Portable Fallout 4 Registry Tool”).
Almost every legacy and modern mod is built to work seamlessly with this version. fallout 4 patch 110163 portable
: By creating a portable folder, you prevent Steam from automatically overwriting your stable game files with newer, mod-breaking patches. How to Create a Portable Fallout 4 1.10.163 Instance
: Ambitious, DLC-sized modifications like Fallout: London were explicitly designed to run on the 1.10.163 architecture. Since this is a "Portable" executable, you do
: Tools like Mod Organizer 2 are ideal for portable setups. They keep your game folder clean by using a "Virtual File System," ensuring that your mods and game files stay exactly as you want them. Summary of Recent Versioning Fallout 4 patches | Fallout Wiki | Fandom
A traditional PC installation ties your game and mod settings directly to Windows Registry entries, AppData configurations, and your local Documents\My Games\Fallout4 folder. Almost every legacy and modern mod is built
Create a new folder on your drive (e.g., C:\PortableGaming\Fallout 4 ).
: Copy the downloaded files from your Steam content folder and overwrite everything in your main Fallout 4 installation directory.